Vuyiseka Dubula is General Secretary of the Treatment Action Campaign (TAC), based in South Africa. As a young woman she joined TAC after learning her HIV positive status. Founded in 1998, TAC advocates for increased access to treatment, care and support services for people living with HIV. Since 1998, TAC has held government accountable for health care service delivery; campaigned against official AIDS denialism; challenged the world’s leading pharmaceutical companies to make treatment more affordable and cultivated community leadership on HIV and AIDS.Today, there are over 2.4 million people on life-saving antiretrovirals in South Africa all funded by the government, but she tells us that her struggle, and more importantly our struggle is not over just yet. Vuyiseka Dubula’s TEDxEuston 2013 talk is a a powerful reminder of the courage it takes to change paradigms when it appears that all the odds are stacked against you. Fighting big companies when you are poor and black was deemed impossible by many people. Fighting the government appeared even more daunting. Vuyiseka did it and lives to tell the tale.